Nickel(ii) complexes with covalently attached quinols rely on ligand-derived redox couples to catalyze superoxide dismutation
Boothe R, Oppelt J, Franke A, Moore JL, Squarcina A, Zahl A, Senft L, Kellner I, Awalah AL, Bradford A, Obisesan SV, Schwartz DD, Ivanović-Burmazović I, Goldsmith CR (2025)
Publication Type: Journal article
Publication year: 2025
Journal
DOI: 10.1039/d4dt03331k
Abstract
Although nickel is found in the active sites of a class of superoxide dismutase (SOD), nickel complexes with non-peptidic ligands normally do not catalyze superoxide degradation, and none has displayed activity comparable to those of the best manganese-containing SOD mimics. Here, we find that nickel complexes with polydentate quinol-containing ligands can exhibit catalytic activity comparable to those of the most efficient manganese-containing SOD mimics. The nickel complexes retain a significant portion of their activity in phosphate buffer and under operando conditions and rely on ligand-centered redox processes for catalysis. Although nickel SODs are known to cycle through Ni(ii) and Ni(iii) species during catalysis, cryo-mass spectrometry studies indicate that the nickel atoms in our catalysts remain in the +2 oxidation state throughout SOD mimicry.
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Germany (DE)
United States (USA) (US)How to cite
APA:
Boothe, R., Oppelt, J., Franke, A., Moore, J.L., Squarcina, A., Zahl, A.,... Goldsmith, C.R. (2025). Nickel(ii) complexes with covalently attached quinols rely on ligand-derived redox couples to catalyze superoxide dismutation. Dalton Transactions. https://doi.org/10.1039/d4dt03331k
MLA:
Boothe, Robert, et al. "Nickel(ii) complexes with covalently attached quinols rely on ligand-derived redox couples to catalyze superoxide dismutation." Dalton Transactions (2025).
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