Fischer S, Neurath M (2025)
Publication Type: Journal article
Publication year: 2025
DOI: 10.1007/s00108-024-01838-5
Background: The pathophysiology of inflammatory bowel diseases is not fully understood. In a staged model by the European Crohn’s and Colitis Organization (ECCO) regarding disease development, it is assumed that there is a population at risk for manifestation of disease following subtle changes over time. Objective: This work aims to summarize the current state of knowledge regarding the pathophysiology, prediction and prevention of chronic inflammatory bowel diseases. Materials and Methods: Selective literature research via PubMed. Results: Several genetic, biochemical, and microbiome scores have the potential to identify individuals at increased risk of developing inflammatory bowel disease, possibly up to a decade before onset. Discussion: The growing knowledge regarding the pathogenesis of inflammatory bowel diseases makes prediction before disease onset a possible future diagnostic goal. Hypothetically, early changes before the disease manifests could be reversible and may be amenable to prevention programs.
APA:
Fischer, S., & Neurath, M. (2025). Update zur Pathophysiologie, Prädiktion und Prävention chronisch-entzündlicher Darmerkrankungen. Innere Medizin. https://doi.org/10.1007/s00108-024-01838-5
MLA:
Fischer, Sarah, and Markus Neurath. "Update zur Pathophysiologie, Prädiktion und Prävention chronisch-entzündlicher Darmerkrankungen." Innere Medizin (2025).
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