Long-term cultivation of retinal pigment epithelium cells on nanofiber scaffolds
Zimmermann JA, Irlenbusch L, Hansen U, Himmler M, Zeng C, Eter N, Fuchsluger T, Heiduschka P (2025)
Publication Type: Journal article
Publication year: 2025
Journal
DOI: 10.1007/s00417-024-06707-3
Abstract
What is known : Key Messages : Retinal pigment epithelium (RPE) cells play an important role in the pathogenesis of degenerative retinal diseases. One therapeutic approach is to transplant healthy RPE cells into the subretinal space. Various nanofiber scaffolds have been used in the past to replace Bruch's membrane. What is new : RPE cells can be stably cultured on polycaprolactone (PCL) and collagen nanofiber scaffolds for up to one year. RPE cells show characteristic properties in terms of cell number, morphology and secretion behaviour on PCL/collagen nanofiber scaffolds.
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Germany (DE)How to cite
APA:
Zimmermann, J.A., Irlenbusch, L., Hansen, U., Himmler, M., Zeng, C., Eter, N.,... Heiduschka, P. (2025). Long-term cultivation of retinal pigment epithelium cells on nanofiber scaffolds. Graefes Archive For Clinical and Experimental Ophthalmology. https://doi.org/10.1007/s00417-024-06707-3
MLA:
Zimmermann, Julian A., et al. "Long-term cultivation of retinal pigment epithelium cells on nanofiber scaffolds." Graefes Archive For Clinical and Experimental Ophthalmology (2025).
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