About-Weekly Pattern in the Dynamic Complexity of a Healthy Subject’s Cellular Immune Activity: A Biopsychosocial Analysis
Seizer L, Cornélissen-Guillaume G, Schiepek G, Chamson E, Bliem HR, Schubert C (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 13
DOI: 10.3389/fpsyt.2022.799214
Abstract
In a previous integrative single-case study, we collected biological, psychological and social time-series data on a 25-year-old healthy woman over the course of 126 12-h intervals (63 days) and used urinary neopterin as an indicator of cellular immune activity [Schubert et al. 2012 (1)]. The present re-evaluation introduced Dynamic Complexity (DC) as an additional non-linear and non-stationary measure to further investigate the subject’s biopsychosocial dynamics during the study. The new time series dealing with urinary neopterin complexity revealed a cyclic, circaseptan (about-weekly) repeating pattern (6.59 days). The only weekly reoccurring events over the course of the study that were associated with this immunological pattern were the in-depth interviews with the subject (mean distance between interviews: 6.5 days). Superposed epoch analysis (SEA) revealed a U-shaped relation between neopterin complexity and interviews, with a decrease in neopterin complexity before and during interviews and an increase after interviews. Furthermore, the complexity scores for irritation, anxiousness/depressiveness and mental activity were positively correlated with neopterin complexity. The results suggest that the interviews, which had been found to be related to the subject’s need for educational and/or social accomplishment, were marked by stress (decrease in psycho-immunological flexibility and adaptability), which was then relieved after the interviews (increase in psycho-immunological flexibility and adaptability). It appears that the subject’s cellular immune activity, as indicated by neopterin complexity, functionally mirrored the emotional meaning she ascribed to the in-depth interviews. This re-evaluation is in line with the view that biopsychosocial research requires multimodal analysis of single cases based on qualitative (e.g., in-depth interviews) and quantitative (e.g., time series analysis) data under conditions of “life as it is lived”.
Authors with CRIS profile
Involved external institutions
Paracelsus Medizinische Privatuniversität
Austria (AT)
Leopold-Franzens-Universität Innsbruck / University of Innsbruck
Austria (AT)
University of Minnesota (UMN)
United States (USA) (US)
Austria (AT)
Leopold-Franzens-Universität Innsbruck / University of Innsbruck
Austria (AT)
University of Minnesota (UMN)
United States (USA) (US)
How to cite
APA:
Seizer, L., Cornélissen-Guillaume, G., Schiepek, G., Chamson, E., Bliem, H.R., & Schubert, C. (2022). About-Weekly Pattern in the Dynamic Complexity of a Healthy Subject’s Cellular Immune Activity: A Biopsychosocial Analysis. Frontiers in Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.799214
MLA:
Seizer, Lennart, et al. "About-Weekly Pattern in the Dynamic Complexity of a Healthy Subject’s Cellular Immune Activity: A Biopsychosocial Analysis." Frontiers in Psychiatry 13 (2022).
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