Improving tumor budding reporting in colorectal cancer: a Delphi consensus study

Haddad TS, Lugli A, Aherne S, Barresi V, Terris B, Bokhorst JM, Brockmoeller SF, Cuatrecasas M, Simmer F, El-Zimaity H, Fléjou JF, Gibbons D, Cathomas G, Kirsch R, Kuhlmann TP, Langner C, Loughrey MB, Riddell R, Ristimäki A, Kakar S, Sheahan K, Treanor D, van der Laak J, Vieth M, Zlobec I, Nagtegaal ID (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Book Volume: 479

Pages Range: 459-469

Journal Issue: 3

DOI: 10.1007/s00428-021-03059-9

Abstract

Tumor budding is a long-established independent adverse prognostic marker in colorectal cancer, yet methods for its assessment have varied widely. In an effort to standardize its reporting, a group of experts met in Bern, Switzerland, in 2016 to reach consensus on a single, international, evidence-based method for tumor budding assessment and reporting (International Tumor Budding Consensus Conference [ITBCC]). Tumor budding assessment using the ITBCC criteria has been validated in large cohorts of cancer patients and incorporated into several international colorectal cancer pathology and clinical guidelines. With the wider reporting of tumor budding, new issues have emerged that require further clarification. To better inform researchers and health-care professionals on these issues, an international group of experts in gastrointestinal pathology participated in a modified Delphi process to generate consensus and highlight areas requiring further research. This effort serves to re-affirm the importance of tumor budding in colorectal cancer and support its continued use in routine clinical practice.

Involved external institutions

Helsingin yliopisto / University of Helsinki Finland (FI) St Vincent's University Hospital Ireland (IE) University of Leeds United Kingdom (GB) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) Universität Bern Switzerland (CH) Universität Bayreuth Germany (DE) University of Verona / Università degli Studi di Verona Italy (IT) Gentofte Hospital Denmark (DK) Medizinische Universität Graz Austria (AT) Royal Victoria Hospital United Kingdom (GB) Hôpital Cochin France (FR) Hospital Clínic de Barcelona Spain (ES) Dynacare Laboratory and Health Services Centre Canada (CA) Hôpital Saint-Antoine France (FR) Kantonsspital Baselland Switzerland (CH) University of California San Francisco (UCSF) United States (USA) (US)

How to cite

APA:

Haddad, T.S., Lugli, A., Aherne, S., Barresi, V., Terris, B., Bokhorst, J.M.,... Nagtegaal, I.D. (2021). Improving tumor budding reporting in colorectal cancer: a Delphi consensus study. Virchows Archiv, 479(3), 459-469. https://doi.org/10.1007/s00428-021-03059-9

MLA:

Haddad, Tariq Sami, et al. "Improving tumor budding reporting in colorectal cancer: a Delphi consensus study." Virchows Archiv 479.3 (2021): 459-469.

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