No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

Dong J, Gharahkhani P, Chow WH, Gammon MD, Liu G, Caldas C, Wu AH, Ye W, Onstad L, Anderson LA, Bernstein L, Pharoah PD, Risch HA, Corley DA, Fitzgerald RC, Iyer PG, Reid BJ, Lagergren J, Shaheen NJ, Vaughan TL, MacGregor S, Love S, Palles C, Tomlinson I, Gockel I, May A, Gerges C, Anders M, Böhmer AC, Becker J, Kreuser N, Thieme R, Noder T, Venerito M, Veits L, Schmidt T, Schmidt C, Izbicki JR, Hölscher AH, Lang H, Lorenz D, Schumacher B, Mayershofer R, Vashist Y, Ott K, Vieth M, Weismüller J, Nöthen MM, Moebus S, Knapp M, Peters WH, Neuhaus H, Rösch T, Ell C, Jankowski J, Schumacher J, Neale RE, Whiteman DC, Thrift AP (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 17

Pages Range: 2227-2235.e1

Journal Issue: 11

DOI: 10.1016/j.cgh.2019.01.041

Abstract

Background & Aims: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study to determine the associations between circulating concentrations of 25(OH)D and risks of EAC and its precursor, Barrett's esophagus (BE). Methods: We conducted a Mendelian randomization study using a 2-sample (summary data) approach. Six single-nucleotide polymorphisms (SNPs; rs3755967, rs10741657, rs12785878, rs10745742, rs8018720, and rs17216707) associated with circulating concentrations of 25(OH)D were used as instrumental variables. We collected data from 6167 patients with BE, 4112 patients with EAC, and 17,159 individuals without BE or EAC (controls) participating in the Barrett's and Esophageal Adenocarcinoma Consortium, as well as studies from Bonn, Germany, and Cambridge and Oxford, United Kingdom. Analyses were performed separately for BE and EAC. Results: Overall, we found no evidence for an association between genetically estimated 25(OH)D concentration and risk of BE or EAC. The odds ratio per 20 nmol/L increase in genetically estimated 25(OH)D concentration for BE risk estimated by combining the individual SNP association using inverse variance weighting was 1.21 (95% CI, 0.77–1.92; P = .41). The odds ratio for EAC risk, estimated by combining the individual SNP association using inverse variance weighting, was 0.68 (95% CI, 0.39–1.19; P = .18). Conclusions: In a Mendelian randomization study, we found that low genetically estimated 25(OH)D concentrations were not associated with risk of BE or EAC.

Involved external institutions

Baylor College of Medicine United States (USA) (US) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Klinikum Bayreuth Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Yale University United States (USA) (US) Kaiser Permanente United States (USA) (US) University of Cambridge United Kingdom (GB) Mayo Clinic United States (USA) (US) Fred Hutchinson Cancer Research Center United States (USA) (US) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) University of Oxford United Kingdom (GB) University of Birmingham United Kingdom (GB) Universitätsklinikum Leipzig Germany (DE) Sana Kliniken AG Germany (DE) Karolinska Institute Sweden (SE) University of North Carolina at Chapel Hill United States (USA) (US) Otto-von-Guericke-Universität Magdeburg Germany (DE) University of Texas MD Anderson Cancer Center United States (USA) (US) Princess Margaret Cancer Centre / Princess Margaret Hospital Canada (CA) Cancer Research UK United Kingdom (GB) Keck School of Medicine of USC United States (USA) (US) Queen's University United Kingdom (GB) City of Hope Medical Center United States (USA) (US) Universität Duisburg-Essen (UDE) Germany (DE) Evangelisches Krankenhaus Düsseldorf Germany (DE) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) Netherlands (NL) Klinikum Darmstadt Germany (DE) Elisabeth-Krankenhaus Essen Germany (DE) Royal College of Surgeons in Ireland (RCSI) Ireland (IE) Universität zu Köln Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE)

How to cite

APA:

Dong, J., Gharahkhani, P., Chow, W.H., Gammon, M.D., Liu, G., Caldas, C.,... Thrift, A.P. (2019). No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study. Clinical Gastroenterology and Hepatology, 17(11), 2227-2235.e1. https://doi.org/10.1016/j.cgh.2019.01.041

MLA:

Dong, Jing, et al. "No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study." Clinical Gastroenterology and Hepatology 17.11 (2019): 2227-2235.e1.

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