Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma

Becker J, May A, Gerges C, Anders M, Veits L, Weise K, Czamara D, Lyros O, Manner H, Terheggen G, Venerito M, Noder T, Mayershofer R, Hofer JH, Karch HW, Ahlbrand CJ, Arras M, Hofer S, Mangold E, Heilmann-Heimbach S, Heinrichs SK, Hess T, Kiesslich R, Izbicki JR, Hölscher AH, Bollschweiler E, Malfertheiner P, Lang H, Moehler M, Lorenz D, Müller-Myhsok B, Ott K, Schmidt T, Whiteman DC, Vaughan TL, Nöthen MM, Hackelsberger A, Schumacher B, Pech O, Vashist Y, Vieth M, Weismüller J, Neuhaus H, Rösch T, Ell C, Gockel I, Schumacher J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Cancer Medicine Wiley Open Access

Book Volume: 4

Pages Range: 1700-1704

Journal Issue: 11

DOI: 10.1002/cam4.500

Abstract

The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P <  10-4 in the BEACON sample. In total, we tested 88 SNPs in an independent sample consisting of 1065 EAC cases and 1019 controls of German descent. We could replicate the association at FOXP1, BARX1, and FOXF1 with nominal significance and thereby confirm that genetic variants at these genes confer EAC risk. In addition, we found association of variants near the genes XRCC2 and GATA6 that were strongly (P < 10-5) although not genome-wide significantly associated with the BEACON GWAS. Therefore, both variants and corresponding genes represent promising candidates for future EAC association studies on independent samples.

Involved external institutions

Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Sana Kliniken AG DE Germany (DE) Evangelisches Krankenhaus Düsseldorf DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Klinikum Bayreuth DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Universität zu Köln DE Germany (DE) Universitätsklinikum Leipzig DE Germany (DE) Max-Planck-Institut für Psychiatrie (Deutsche Forschungsanstalt für Psychiatrie) DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) RoMed Kliniken - Kliniken der Stadt und des Landkreises Rosenheim GmbH DE Germany (DE) QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) AU Australia (AU) University of Washington US United States (USA) (US) Krankenhaus Barmherzige Brüder DE Germany (DE)

How to cite

APA:

Becker, J., May, A., Gerges, C., Anders, M., Veits, L., Weise, K.,... Schumacher, J. (2015). Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma. Cancer Medicine, 4(11), 1700-1704. https://doi.org/10.1002/cam4.500

MLA:

Becker, Jessica, et al. "Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma." Cancer Medicine 4.11 (2015): 1700-1704.

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