Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care - A 5-year follow-up

Jaspersen D, Nocon M, Labenz J, Leodolter A, Richter K, Stolte M, Vieth M, Lind T, Willich SN, Malfertheiner P (2009)

Publication Type: Journal article

Publication year: 2009

Journal

Alimentary Pharmacology & Therapeutics Wiley-Blackwell

Book Volume: 29

Pages Range: 1172-1178

Journal Issue: 11

DOI: 10.1111/j.1365-2036.2009.03981.x

Abstract

Background Gastro-oesophageal reflux disease (GERD) can be associated with laryngo-respiratory symptoms (LRS) such as chronic cough, asthma or laryngeal symptoms. Aim To analyse the long-term clinical course of LRS in a large population with GERD and LRS. Methods ProGERD is a prospective multicentre cohort study of 6215 adult out-patients with GERD. At baseline, the prevalence of LRS was assessed. Initial standardized treatment was esomeprazole for up to 8 weeks. After 5 years of follow-up, patients were interviewed for LRS and a multivariate analysis was performed with resolved vs. persistent symptoms for chronic cough, asthma and laryngeal symptoms. Results In all, 2886 patients (46.4%) were available for analysis at baseline and at 5 years. The prevalence of chronic cough and laryngeal disorders had decreased while the prevalence of asthma had increased. Resolution of LRS was independent of clinical reflux characteristics or PPI medication. Conclusions In a large population with GERD, only few patients reported persistent LRS over 5 years. Resolution of LRS was independent of the stage of GERD and PPI treatment. Accordingly, data on the direction of causality between GERD and LRS are lacking and the strength of the association between the two must remain controversial. © 2009 Blackwell Publishing Ltd.

Involved external institutions

Diakonie Klinikum Jung-Stilling DE Germany (DE) University of Cambridge GB United Kingdom (GB) Klinikum Bayreuth DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Klinikum Fulda DE Germany (DE)

How to cite

APA:

Jaspersen, D., Nocon, M., Labenz, J., Leodolter, A., Richter, K., Stolte, M.,... Malfertheiner, P. (2009). Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care - A 5-year follow-up. Alimentary Pharmacology & Therapeutics, 29(11), 1172-1178. https://doi.org/10.1111/j.1365-2036.2009.03981.x

MLA:

Jaspersen, D., et al. "Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine care - A 5-year follow-up." Alimentary Pharmacology & Therapeutics 29.11 (2009): 1172-1178.

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