Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study
Nocon M, Labenz J, Jaspersen D, Leodolter A, Richter K, Vieth M, Lind T, Malfertheiner P, Willich SN (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 29
Pages Range: 662-668
Journal Issue: 6
DOI: 10.1111/j.1365-2036.2008.03921.x
Abstract
Background : Gastro-oesophageal reflux disease (GERD) is a common disorder associated with substantial reductions in health-related quality of life (HRQL). Aim : To describe patterns of change in HRQL during 5 years of follow-up in a large population of GERD patients. Methods : In 2000, a total of 6215 GERD patients were enrolled in the Progression of GERD (ProGERD) study. During follow-up, patients received any medication considered necessary. HRQL was assessed yearly with the Short-Form 36 and the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaires. Associations between patient characteristics and changes in HRQL were analysed using multiple logistic regression models. Results : After 5 years, data on HRQL were available for 4597 (74%) patients. Both generic and disease-specific HRQL improved after baseline and remained well above baseline levels in the following years. A clinically relevant decrease in QOLRAD scores was reported by 3-5% of patients. According to our multivariate analysis, a decrease in HRQL was associated with a higher reflux symptom load and the presence of night-time heartburn. Conclusions : Only a small minority of the ProGERD population reported a clinically relevant decrease in HRQL, which was associated most strongly with nocturnal heartburn. © 2009 Blackwell Publishing Ltd.
Involved external institutions
Charité - Universitätsmedizin Berlin
Germany (DE)
Diakonie Klinikum Jung-Stilling
Germany (DE)
Klinikum Fulda
Germany (DE)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Klinikum Bayreuth
Germany (DE)
Germany (DE)
Diakonie Klinikum Jung-Stilling
Germany (DE)
Klinikum Fulda
Germany (DE)
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Klinikum Bayreuth
Germany (DE)
How to cite
APA:
Nocon, M., Labenz, J., Jaspersen, D., Leodolter, A., Richter, K., Vieth, M.,... Willich, S.N. (2009). Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study. Alimentary Pharmacology & Therapeutics, 29(6), 662-668. https://doi.org/10.1111/j.1365-2036.2008.03921.x
MLA:
Nocon, M., et al. "Health-related quality of life in patients with gastro-oesophageal reflux disease under routine care: 5-year follow-up results of the ProGERD study." Alimentary Pharmacology & Therapeutics 29.6 (2009): 662-668.
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