Macrophages hit a nerve in painful joint venture: Neuroimmunology

Ben Brahim O, Uderhardt S (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Nature Reviews Rheumatology Nature Publishing Group

Article Number: 121

DOI: 10.1038/s41584-025-01227-8

Abstract

Hasegawa et al. reveal how synovial joints detect systemic inflammation through specialized fenestrated blood vessels at the synovial periphery. Three distinct macrophage populations and nociceptor neurons form a sentinel unit around these vessels, coordinating immune responses and pain signalling through interleukin-1β (IL-1β) and calcitonin gene-related peptide (CGRP) signalling.

Authors with CRIS profile

Oumaima Ben Brahim Department of Medicine 3 – Rheumatology and Immunology Stefan Uderhardt Department of Medicine 3 – Rheumatology and Immunology

How to cite

APA:

Ben Brahim, O., & Uderhardt, S. (2025). Macrophages hit a nerve in painful joint venture: Neuroimmunology. Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-025-01227-8

MLA:

Ben Brahim, Oumaima, and Stefan Uderhardt. "Macrophages hit a nerve in painful joint venture: Neuroimmunology." Nature Reviews Rheumatology (2025).

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