Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor α mutations

Agaimy A, Wang LM, Eck M, Haller F, Chetty R (2013)

Publication Language: English

Publication Type: Journal article

Publication year: 2013

Journal

Annals of Diagnostic Pathology WB Saunders

Book Volume: 17

Pages Range: 187-191

Journal Issue: 2

DOI: 10.1016/j.anndiagpath.2012.10.005

Abstract

Most gastric gastrointestinal stromal tumors (GISTs) display spindle cell morphology and coexpress CD117 (KIT), DOG-1, and CD34. Secondary loss of DOG-1 has not been reported. We present two gastric GISTs which showed loss of DOG-1 in the epithelioid component but retained its expression in the minor spindle cell component. Patients were a 67-year-old man and an 80-year-old woman with 4.8-cm and 3.5-cm gastric GISTs harboring mutations in KIT exon 11 (c.1729-1758dup30; p.P577-R586dup) and platelet-derived growth factor receptor α (PDGFRA) exon 18 (c.2527-2538del12; p.I843-D846del), respectively. Both were predominantly epithelioid with a minor microscopic spindle cell component (3-12 mm). The spindle cell component was CD117+CD34 +DOG-1+ in both cases. The epithelioid component in case 1 was CD117+CD34+DOG-1-. In case 2, the epithelioid component strongly expressed PDGFRA (dot-like) but lost CD117, CD34, and DOG-1. These cases confirm the immunophenotypic heterogeneity as secondary events in GIST. Loss of DOG-1 in KIT-negative PDGFRA mutants should not preclude diagnosis. © 2013 Elsevier Inc. All rights reserved.

Authors with CRIS profile

Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Florian Haller Professur für Diagnostische Molekularpathologie

Involved external institutions

Klinikum Aschaffenburg DE Germany (DE) University of Oxford GB United Kingdom (GB)

How to cite

APA:

Agaimy, A., Wang, L.M., Eck, M., Haller, F., & Chetty, R. (2013). Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor α mutations. Annals of Diagnostic Pathology, 17(2), 187-191. https://doi.org/10.1016/j.anndiagpath.2012.10.005

MLA:

Agaimy, Abbas, et al. "Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor α mutations." Annals of Diagnostic Pathology 17.2 (2013): 187-191.

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