Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH

Schaefer IM, Enders C, Polten A, Haller F, Frölich AM, Cameron S, Schüler P, Schweiger P, Gunawan B, Beham A, Füzesi L (2011)

Publication Type: Journal article

Publication year: 2011

Journal

American Journal of Clinical Pathology J B Lippincott Co

Book Volume: 135

Pages Range: 579-586

Journal Issue: 4

DOI: 10.1309/AJCPZ1O7UUUISPNR

Abstract

Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common chromosomal gains at 2p25.3-2p12, 7q21.3-7q22.3, and 11q13.2-11q13.4. Chromosomal losses at 13q31qter were observed in both carcinosarcomas. In addition, progression of genomic instability from in situ to invasive carcinosarcoma could be demonstrated by using array CGH. Our observations suggest a common genetic origin of BSCC and carcinosarcoma. © American Society for Clinical Pathology.

Involved external institutions

Universitätsklinikum Göttingen DE Germany (DE) Agilent Technologies (Germany) DE Germany (DE) Evangelisches Krankenhaus Göttingen-Weende DE Germany (DE)

How to cite

APA:

Schaefer, I.M., Enders, C., Polten, A., Haller, F., Frölich, A.M., Cameron, S.,... Füzesi, L. (2011). Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH. American Journal of Clinical Pathology, 135(4), 579-586. https://doi.org/10.1309/AJCPZ1O7UUUISPNR

MLA:

Schaefer, Inga Marie, et al. "Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH." American Journal of Clinical Pathology 135.4 (2011): 579-586.

BibTeX: Download