Multilayer analysis of signal transduction and cell cycle control in GIST. Indentifying new interaction partners with differential regulation Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation
Haller F, Zhang DJ, Löbke C, Von Heydebreck A, Korf U, Füzesi L, Sahin Ö (2010)
Publication Type: Journal article
Publication year: 2010
Journal
Book Volume: 31
Pages Range: 134-137
Journal Issue: SUPPL. 2
DOI: 10.1007/s00292-010-1339-5
Abstract
To identify new interactions as well as diagnostically, prognostically and therapeutically relevant differences in the regulation of gene expression in gastrointestinal stromal tumors (GISTs), we analyzed the methylation status, mRNA expression, microRNA expression, protein expression and protein phosphorylation in parallel in identical tumor tissue samples. The data were analyzed in a multilayer approach and were correlated to each other and to clinico-pathological parameters. Differentially regulated genes were mapped to signal transduction pathways which are already known to play a major role in GISTs. A functionally orientated overview of the different data layers was constructed, which enabled new insights into gene regulation in GISTs. © Springer-Verlag 2010.
Involved external institutions
Universitätsklinikum Freiburg
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Merck KGaA
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
Germany (DE)
Deutsches Krebsforschungszentrum (DKFZ)
Germany (DE)
Merck KGaA
Germany (DE)
Universitätsklinikum Göttingen
Germany (DE)
How to cite
APA:
Haller, F., Zhang, D.J., Löbke, C., Von Heydebreck, A., Korf, U., Füzesi, L., & Sahin, Ö. (2010). Multilayer analysis of signal transduction and cell cycle control in GIST. Indentifying new interaction partners with differential regulation Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation. Pathologe, 31(SUPPL. 2), 134-137. https://doi.org/10.1007/s00292-010-1339-5
MLA:
Haller, F., et al. "Multilayer analysis of signal transduction and cell cycle control in GIST. Indentifying new interaction partners with differential regulation Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation." Pathologe 31.SUPPL. 2 (2010): 134-137.
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