The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset

Fornaro M, Venerito V, Pellico MR, Iannone F, Joshi M, Chen YM, Tan AL, Saha S, Chatterjee T, Agarwal V, Shinjo SK, Hoff LS, Kadam E, Ziade N, Velikova T, Hasan AT, Shumnalieva R, Milchert M, Tan CL, Gracia-Ramos AE, Cavagna L, Vaidya B, Kuwana M, Shaharir SS, Knitza J, Makol A, Tehozol EAZ, Serrano JR, Halabi H, Dey D, Toro-Gutiérrez CE, Goo PA, Caballero-Uribe CV, Distler O, Katchamart W, Day J, Parodis I, Nikiphorou E, Chinoy H, Agarwal V, Gupta L, Sen P, Javaid M, Andreoli L, Lini D, Schreiber K, Nune A, Patel A, Pauling JD, Wincup C, Barman B, García-De La Torre I, Colunga-Pedraza IJ, Merayo-Chalico J, Chibuzo OC, El Kibbi L, Lilleker JB, Salim B, Gheita T, Saavedra MA, Griger Z, Kardes S, Vince MN, Singh YP, Ranjan R, Jain A, Pandya SC, Pilania RK, Sharma A, Manoj MM, Gupta V, Kavadichanda CG, Patro PS, Ajmani S, Phatak S, Goswami RP, Chowdhury AC, Mathew AJ, Shenoy P, Asranna A, Bommakanti KT, Shukla A, Pande AR, Chandwar K, Ghodke A, Boro H, Fazal ZZ, Cansu DÜ, Yıldırım R, Gasparyan AY, Del Papa N, Sambataro G, Fabiola A, Govoni M, Parisi S, Bocci EB, Sebastiani GD, Fusaro E, Sebastiani M, Quartuccio L, Franceschini F, Sainaghi PP, Orsolini G, De Angelis R, Danieli MG, Grignaschi S, Giollo A, Alunno A, Traboco LS, Wibowo SAK, Loarce-Martos J, Prieto-González S, Gonzalez RA, Yoshida A, Nakashima R, Sato S, Kimura N, Kaneko Y, Gono T, Tomaras S, Proft FN, Holzer MT, Gromova MA, Aharonov O, Hmamouchi I, El bouchti I, Baba Z, Giannini M, Maurier F, Campagne J, Meyer A, Langguth D, Limaye V, Needham M, Srivastav N, Hudson M, Landon-Cardinal O, Zuleta WGR, Arbeláez Á, Cajas J, Silva JAP, Fonseca JE, Zimba O, Ima-Edomwonyi U, Dedeke I, Airenakho E, Madu NH, Yerima A, Olaosebikan H, Becky A, Koussougbo OD, Palalane E, So H, Ugarte-Gil MF, Chinchay L, Bernaola JP, Pimentel V, Fathi HM, Mohammed RHA, Harifi G, Fuentes-Silva Y, Cabriza K, Losanto J, Colaman N, Cachafeiro-Vilar A, Bautista GG, Ho EJG, González R, Nunez LS, Vergara CM, Báez JT, Alonzo H, Pastelin CBS, Salinas RG, Obiols AQ, Chávez N, Ordóñez AB, Argueta S, Llerena GAR, Sierra-Zorita R, Arrieta D, Hidalgo ER, Saenz R, Escalante IM, Morales R, Calapaqui W, Quezada I, Arredondo G (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

Book Volume: 64

Pages Range: 2133-2142

Journal Issue: 4

DOI: 10.1093/rheumatology/keae520

Abstract

Objective: The presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited. Methods: We examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping. Results: Among the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P<0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P<0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P<0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P<0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P<0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores. Conclusion: Patients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.

Authors with CRIS profile

Involved external institutions

University of Bari Aldo Moro / Università degli Studi di Bari Aldo Moro Italy (IT) Università degli studi di Milano Italy (IT) Byramjee Jeejeebhoy Government Medical College & Sassoon General Hospital India (IN) Taichung Veterans General Hospital Taiwan (TW) NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU) United Kingdom (GB) Mymensingh Medical College / ময়মনসিংহ মেডিকেল কলেজ Bangladesh (BD) University of Illinois at Chicago United States (USA) (US) Mahatma Gandhi Mission Medical College and Hospital India (IN) University of São Paulo / Universidade de São Paulo (USP) Brazil (BR) Universidade Potiguar (UnP) Brazil (BR) King Edward Memorial Hospital and Seth G.S. Medical College / கிங் எட்வர்ட் நினைவு மருத்துவமனை,राजा एड्वर्ड स्मारक रुग्णालय व सेठ गोवर्धनदास सुंदरदास वैद्यकीय महाविद्यालय India (IN) Université Saint-Joseph (USJ) / جامعة القديس يوسف / Սուրբ Ժոզեֆի համալսարան Lebanon (LB) Sofia University "St. Kliment Ohridski" / Софийски университет "Св. Климент Охридски" Bulgaria (BG) Green Life Medical College Bangladesh (BD) University Hospital St. Ivan Rilski Bulgaria (BG) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Queen Savang Vadhana Memorial Hospital / โรงพยาบาลสมเด็จพระบรมราชเทวี ณ ศรีราชา Thailand (TH) Universidad del Norte Colombia (CO) Universitätsspital Zürich (USZ) Switzerland (CH) Siriraj Hospital Thailand (TH) Walter and Eliza Hall Institute of Medical Research (WEHI) Australia (AU) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) King’s College London United Kingdom (GB) Health Innovation Manchester United Kingdom (GB) Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) India (IN) Hospital Sultanah Bahiyah (HSB) Malaysia (MY) Instituto Mexicano del Seguro Social Mexico (MX) Università degli Studi di Pavia Italy (IT) National Center for Rheumatic Diseases (NCRD) Nepal (NP) University of Malaya (UM) / Universiti Malaya Malaysia (MY) Mayo Clinic United States (USA) (US) Instituto Nacional de Enfermedades Respiratorias Mexico (MX) King Faisal Specialist Hospital & Research Centre Saudi Arabia (SA) University of Ghana Ghana (GH) Pontifical Xavierian University / Pontificia Universidad Javeriana Colombia (CO)

How to cite

APA:

Fornaro, M., Venerito, V., Pellico, M.R., Iannone, F., Joshi, M., Chen, Y.M.,... Arredondo, G. (2025). The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset. Rheumatology, 64(4), 2133-2142. https://doi.org/10.1093/rheumatology/keae520

MLA:

Fornaro, Marco, et al. "The impact of multimorbidity on Quality of Life in inflammatory myopathies: A cluster analysis from the COVAD dataset." Rheumatology 64.4 (2025): 2133-2142.

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