Human IL-6-Producing B Cells Promote the Differentiation of Monocytes Toward an Anti-Inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ Phenotype in Tuberculosis
Bénard A, Balboa L, Caouaille M, Ravon-Katossky L, Meunier E, Fillatreau S, Sasiain MDC, Neyrolles O, Hudrisier D (2025)
Publication Type: Journal article
Publication year: 2025
Journal
Book Volume: 55
Pages Range: e202451509-
Journal Issue: 4
Abstract
The polarization of the monocyte/macrophage compartment toward an anti-inflammatory profile is considered detrimental in tuberculosis (TB), but the factors controlling M2 polarization in this context are still poorly understood. Here, we found that B cells promote the differentiation of human monocytes toward an M2-like activation program through a process primarily dependent on IL-6 and the activation of STAT3 signaling in monocytes. This confers monocytes with immunomodulatory properties characterized by a reduced ability to produce proinflammatory cytokines and to stimulate IFNγ secretion by allogeneic T cells. Our findings were validated using B cells from TB patients, which constitutively produce high levels of IL-6, underscoring the clinical relevance of our experimental observations. Collectively, our results indicate that human B-cell-derived IL-6 might impair TB immunity by driving monocyte polarization toward an anti-inflammatory phenotype.
Involved external institutions
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) / National Scientific and Technical Research Council
Argentina (AR)
Université Toulouse III - Paul Sabatier
France (FR)
Université Sorbonne Paris Cité
France (FR)
Argentina (AR)
Université Toulouse III - Paul Sabatier
France (FR)
Université Sorbonne Paris Cité
France (FR)
How to cite
APA:
Bénard, A., Balboa, L., Caouaille, M., Ravon-Katossky, L., Meunier, E., Fillatreau, S.,... Hudrisier, D. (2025). Human IL-6-Producing B Cells Promote the Differentiation of Monocytes Toward an Anti-Inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ Phenotype in Tuberculosis. European Journal of Immunology, 55(4), e202451509-. https://doi.org/10.1002/eji.202451509
MLA:
Bénard, Alan, et al. "Human IL-6-Producing B Cells Promote the Differentiation of Monocytes Toward an Anti-Inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ Phenotype in Tuberculosis." European Journal of Immunology 55.4 (2025): e202451509-.
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