Böhmer E, Degelmann L, Ni D, Klämpfl F, Schmidt M (2025)
Publication Type: Conference contribution
Publication year: 2025
Publisher: SPIE
Book Volume: 13317
Conference Proceedings Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Event location: San Francisco, CA, USA
ISBN: 9781510683822
DOI: 10.1117/12.3042039
Laser-induced Breakdown Spectroscopy (LIBS) has been demonstrated to be an effective tool in industrial contexts for the analysis of a diverse range of materials, including metals, polymers, and the identification of material composition on Mars. Although LIBS has already demonstrated its value in industrial contexts, it remains relatively unexplored in medical applications, where its potential advantages have not yet been fully realized. Building upon the successful implementation of a LIBS system for metal analysis, this research extended the methodology to biological samples. The objective of this study is to evaluate the requisite conditions for calibration-free LIBS (CF-LIBS) analysis of porcine skin. This tissue was chosen because it is similar to human tissue. The three requisite conditions for CF-LIBS are stoichiometric ablation, optical thin plasma, and local thermodynamic equilibrium (LTE). To fulfill these conditions the temperature was evaluated using the Boltzmann plot, and the electron density was determined using the McWhriter and the Saha-Boltzmann equation. All three methods were evaluated for the elements sodium (Na) and calcium (Ca). The results demonstrated that all three conditions for CF-LIBS could be fulfilled for all investigated elements. Therefore, it is promising that CF-LIBS for biological tissue will be possible in the future.
APA:
Böhmer, E., Degelmann, L., Ni, D., Klämpfl, F., & Schmidt, M. (2025). Preliminary results for calibration-free Laser-induced Breakdown Spectroscopy (CF-LIBS) for the elemental analysis of biological samples. In Norbert Linz, Joel N. Bixler, Alex J. Walsh (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. San Francisco, CA, USA: SPIE.
MLA:
Böhmer, Edith, et al. "Preliminary results for calibration-free Laser-induced Breakdown Spectroscopy (CF-LIBS) for the elemental analysis of biological samples." Proceedings of the Optical Interactions with Tissue and Cells XXXVI 2025, San Francisco, CA, USA Ed. Norbert Linz, Joel N. Bixler, Alex J. Walsh, SPIE, 2025.
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