Feasibility Study of Bioactive Hydrogel Coatings on Ti-6Al-4V Gyroid Scaffolds for Bone Tissue Engineering

Schöbel L, Ayerbe MG, Polley C, Arruebarrena G, Seitz H, Boccaccini AR (2025)

Publication Type: Journal article

Publication year: 2025

Journal

ACS Biomaterials Science and Engineering American Chemical Society

DOI: 10.1021/acsbiomaterials.4c02250

Abstract

Titanium alloys are commonly used for bone replacement due to their excellent corrosion resistance. However, they can cause stress shielding due to their high stiffness. Consequently, porous titanium scaffolds can be designed to reduce the elastic mismatch with bone, and further hydrogel coatings can be applied to mimic the extracellular microenvironment. In this work, gyroid titanium scaffolds were coated with a bioactive alginate-gelatin hydrogel. The addition of 45S5 bioactive glass enhanced the mechanical properties of the hydrogel and its adhesion strength. Furthermore, the developed hydrogels allowed for the penetration of gyroid scaffolds, demonstrating the potential of bioactive coatings for titanium implants.

Authors with CRIS profile

Lisa Schöbel Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universität Rostock DE Germany (DE) Universidad de Mondragón / Mondragon Unibertsitatea (MU) ES Spain (ES)

How to cite

APA:

Schöbel, L., Ayerbe, M.G., Polley, C., Arruebarrena, G., Seitz, H., & Boccaccini, A.R. (2025). Feasibility Study of Bioactive Hydrogel Coatings on Ti-6Al-4V Gyroid Scaffolds for Bone Tissue Engineering. ACS Biomaterials Science and Engineering. https://doi.org/10.1021/acsbiomaterials.4c02250

MLA:

Schöbel, Lisa, et al. "Feasibility Study of Bioactive Hydrogel Coatings on Ti-6Al-4V Gyroid Scaffolds for Bone Tissue Engineering." ACS Biomaterials Science and Engineering (2025).

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