Chronic alcohol consumption leads to a tissue specific expression of uncoupling protein-2
Graw JA, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies CD (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 12
Pages Range: 995-999
Journal Issue: 12
DOI: 10.7150/ijms.13193
Abstract
Uncoupling proteins (UCPs) are anion channels that can decouple the mitochondrial respiratory chain. “Mild uncoupling” of internal respiration reduces free radical production and oxidative cell stress. Chronic alcohol consumption is a potent inducer of oxidative stress in multiple tissues and regulates UCP-2 and -4 expression in the brain. To analyse the impact of chronic alcohol intake on UCP-2 expression in tissues with high endogenous UCP-2 contents, male Wistar rats (n=34) were treated with a 12-week 5% alcohol diet. In the lungs and the spleen of rats with a chronic alcohol diet cytochrome c release from mitochondria was significantly increased. Both organs did not show any altered gene and protein expression of UCP-2. Different to cerebral tissue chronic alcohol consumption has no regulatory effect on UCP-2 gene and protein expression in organs with a high endogenous UCP-2 content. Therefore, chronic alcohol consumption leads to a tissue specific expression of UCP-2.
Involved external institutions
Germany (DE)How to cite
APA:
Graw, J.A., von Haefen, C., Poyraz, D., Möbius, N., Sifringer, M., & Spies, C.D. (2015). Chronic alcohol consumption leads to a tissue specific expression of uncoupling protein-2. International Journal of Medical Sciences, 12(12), 995-999. https://doi.org/10.7150/ijms.13193
MLA:
Graw, Jan A., et al. "Chronic alcohol consumption leads to a tissue specific expression of uncoupling protein-2." International Journal of Medical Sciences 12.12 (2015): 995-999.
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