Delaby C, Ladang A, Martinez-Yriarte J, Zecca C, Logroscino G, Körtvelyessy P, Tumani H, Parchi P, Quadrio I, Hart M, Olsen DA, Alcolea D, Blennow K, Fortea J, Lleo A, Algeciras-Schimnich A, Ayrignac X, Bedel A, Santos GA, Borelli W, Bouaziz-Amar E, Baldeiras I, Bigot-Corbel E, Bjerke M, Carretero Perez M, Casoli T, Chabrashvili T, Chapman MD, Cusato J, Dursun E, Fourier A, Galimberti D, Gezen-Ak D, Gordon BA, Gouju J, de las Heras Florez S, Hernandez Sanchez J, Herwerth M, Imperiale D, Kaczorowski F, Kasuga K, Keshavan A, Khalil M, Kuhle J, Leithner C, Lewczuk P, Letournel F, Tsolaki M, Giuffrè GM, Blanc MC, Mroczko B, Martínez Rodríguez JE, Musso G, Kulczynska-Przybik A, Nogueira L, Paquet C, Baiardi S, Gaetani L, Parnetti L, Perez Garay R, Poesen K, Quillard-Muraine M, Rodriguez Borja E, Schraen S, Terracciano D, Bachhuber F, Halbgebauer S, Tzartos S, Tzartos J, Unterwalder N, Vermunt L, Wellington CL, Zetterberg H, Teunissen C, Lehmann S (2025)
Publication Type: Journal article
Publication year: 2025
Book Volume: 21
Journal Issue: 6
DOI: 10.1002/alz.70343
INTRODUCTION: Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts. METHODS: We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements. RESULTS: Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%). DISCUSSION: Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice. HIGHLIGHTS: Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.
APA:
Delaby, C., Ladang, A., Martinez-Yriarte, J., Zecca, C., Logroscino, G., Körtvelyessy, P.,... Lehmann, S. (2025). Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview. Alzheimers & Dementia, 21(6). https://doi.org/10.1002/alz.70343
MLA:
Delaby, Constance, et al. "Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview." Alzheimers & Dementia 21.6 (2025).
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