Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

Bailey DM, Blottner D, Gunga HC, Schneider S, Wotring V, Baatout S, Durante M, Olde Engberink RH, Goswami N, Heer M, Liphardt AM, Monici M, Pagnini F, Stern C, Stukenborg JB, Weber T, Vico L, White O, van Ombergen A, Choukér A (2025)

Publication Type: Journal article, Review article

Publication year: 2025

Journal

npj microgravity

Book Volume: 11

Article Number: 82

Journal Issue: 1

DOI: 10.1038/s41526-025-00537-1

Abstract

Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.

Authors with CRIS profile

Anna-Maria Liphardt Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Université Jean Monnet Saint-Étienne Université de Bourgogne (uB) / University of Burgundy / University of Dijon European Space Agency (ESA) Klinikum der Universität München (LMU Klinikum) University of South Wales Charité - Universitätsmedizin Berlin Deutsche Sporthochschule Köln International Space University Belgian Nuclear Research Centre (SCK•CEN) / Studiecentrum voor Kernenergie / Centre d'Étude de l'énergie Nucléaire GSI Helmholtzzentrum für Schwerionenforschung GmbH University of Amsterdam Medizinische Universität Graz IU Internationale Hochschule Università degli Studi di Firenze / University of Florence Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR) / German Aerospace Center Karolinska University Hospital / Karolinska Universitetssjukhuset

How to cite

APA:

Bailey, D.M., Blottner, D., Gunga, H.C., Schneider, S., Wotring, V., Baatout, S.,... Choukér, A. (2025). Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit. npj microgravity, 11(1). https://doi.org/10.1038/s41526-025-00537-1

MLA:

Bailey, Damian M., et al. "Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit." npj microgravity 11.1 (2025).

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