Dynamic Transitions for Fast Joint Acquisition and Reconstruction of CEST-Rex and T1

Huemer M, Stilianu C, Scholand N, Mackner D, Uecker M, Zaiß M, Stollberger R (2025)

Publication Type: Journal article

Publication year: 2025

Journal

Magnetic Resonance in Medicine Wiley

DOI: 10.1002/mrm.70198

Abstract

Purpose: This work proposes a method for the simultaneous estimation of the exchange-dependent relaxation rate (Formula presented.) and the longitudinal relaxation time (Formula presented.) from a single acquisition. Methods: A novel acquisition scheme was developed that combines CEST saturation with an inversion pulse and a Look-Locker readout to capture the magnetization evolution starting from the inverse transient Z-spectrum. The corresponding signal model, derived from the Bloch-McConnell equations, describes both the transient Z-spectrum and the Look-Locker dynamics. A model-based reconstruction approach is employed to jointly estimate (Formula presented.) and (Formula presented.). The proposed method was validated using a numerical phantom and benchmarked against conventional CEST and Look-Locker (Formula presented.) mapping in a phantom and in vivo on a clinical 3T scanner. Results: The joint estimation approach demonstrated strong agreement with ground truth and conventional methods across a wide range of (Formula presented.) and CEST parameters. The acquisition time was reduced by 20%–30% compared to standard CEST protocols, while providing a higher signal-to-noise ratio (SNR) in parameter maps. Conclusion: The proposed technique enables robust and efficient simultaneous quantification of CEST (Formula presented.) and (Formula presented.) in a single acquisition. It improves parameter map quality and reduces scan time, making it suitable for both phantom and in vivo imaging across a wide range of physiological conditions.

Authors with CRIS profile

Moritz Zaiß Professur für Multimodale Bildgebung in der klinischen Forschung

Involved external institutions

Technische Universität Graz AT Austria (AT)

How to cite

APA:

Huemer, M., Stilianu, C., Scholand, N., Mackner, D., Uecker, M., Zaiß, M., & Stollberger, R. (2025). Dynamic Transitions for Fast Joint Acquisition and Reconstruction of CEST-Rex and T1. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.70198

MLA:

Huemer, Markus, et al. "Dynamic Transitions for Fast Joint Acquisition and Reconstruction of CEST-Rex and T1." Magnetic Resonance in Medicine (2025).

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