Adult neurogenesis: New neurons, new opportunities

Doludda B, Barde W, D'Egidio F, Fitzsimons CP, Frisén J, Gage FH, Jessberger S, Lazarov O, Lie DC, Lucassen PJ, de Lucia C, Salta E, Song H, Song J, Thuret S, Toda T, Kempermann G (2026)

Publication Type: Journal article, Review article

Publication year: 2026

Journal

Cell Stem Cell Elsevier (Cell Press)

Book Volume: 33

Pages Range: 382-392

Journal Issue: 3

DOI: 10.1016/j.stem.2026.01.014

Abstract

The 38 currently registered clinical trials with the keyword "adult neurogenesis" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.

Authors with CRIS profile

Dieter Chichung Lie Lehrstuhl für Mikroskopische Anatomie und Molekulare Bildgebung

Additional Organisation(s)

Sonderforschungsbereich 1540/1 - Erforschung der Mechanik des Gehirns (EBM): Verständnis, Engineering und Nutzung mechanischer Eigenschaften und Signale in der Entwicklung, Physiologie und Pathologie des zentralen Nervensystems

Involved external institutions

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) DE Germany (DE) University of L'Aquila / Università degli Studi dell'Aquila IT Italy (IT) University of Amsterdam NL Netherlands (NL) Karolinska Institute SE Sweden (SE) Salk Institute for Biological Studies US United States (USA) (US) University of Zurich / Universität Zürich (UZH) CH Switzerland (CH) University of Illinois at Chicago US United States (USA) (US) King’s College London GB United Kingdom (GB) The Netherlands Institute for Neuroscience NL Netherlands (NL) University of Pennsylvania (UPenn) US United States (USA) (US) University of North Carolina at Chapel Hill US United States (USA) (US)

How to cite

APA:

Doludda, B., Barde, W., D'Egidio, F., Fitzsimons, C.P., Frisén, J., Gage, F.H.,... Kempermann, G. (2026). Adult neurogenesis: New neurons, new opportunities. Cell Stem Cell, 33(3), 382-392. https://doi.org/10.1016/j.stem.2026.01.014

MLA:

Doludda, Birte, et al. "Adult neurogenesis: New neurons, new opportunities." Cell Stem Cell 33.3 (2026): 382-392.

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