Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?

Strauß M, Reif A, Ulke C, Paucke M, Sander C, Hegerl U, Weber H, Heupel J, Kopf J, Kittel-Schneider S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

European archives of psychiatry and clinical neuroscience Springer Verlag (Germany)

Book Volume: 270

Pages Range: 1073-1076

Journal Issue: 8

DOI: 10.1007/s00406-019-01085-y

Abstract

We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95% CI 1.0–1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response.

Involved external institutions

Universitätsklinikum Leipzig DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Strauß, M., Reif, A., Ulke, C., Paucke, M., Sander, C., Hegerl, U.,... Kittel-Schneider, S. (2020). Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients? European archives of psychiatry and clinical neuroscience, 270(8), 1073-1076. https://doi.org/10.1007/s00406-019-01085-y

MLA:

Strauß, Maria, et al. "Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?" European archives of psychiatry and clinical neuroscience 270.8 (2020): 1073-1076.

BibTeX: Download