Meta-analysis of the DRD5 VNTR in persistent ADHD
Klein M, Berger S, Hoogman M, Dammers J, Makkinje R, Heister AJ, Galesloot TE, Kiemeney LA, Weber H, Kittel-Schneider S, Lesch KP, Reif A, Ribasés M, Ramos-Quiroga JA, Cormand B, Zayats T, Hegvik TA, Jacobsen KK, Johansson S, Haavik J, Mota NR, Bau CH, Grevet EH, Doyle A, Faraone SV, Arias-Vásquez A, Franke B (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 26
Pages Range: 1527-1532
Journal Issue: 9
DOI: 10.1016/j.euroneuro.2016.06.012
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts. Our findings provide evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.
Involved external institutions
Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC)
Netherlands (NL)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
University of Bergen / Universitetet i Bergen
Norway (NO)
Haukeland University Hospital / Haukeland universitetssykehus
Norway (NO)
Universidade Federal do Rio Grande do Sul (UFRGS)
Brazil (BR)
Hospital de Clínicas de Porto Alegre (HCPA)
Brazil (BR)
Massachusetts General Hospital
United States (USA) (US)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Spain (ES)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
Netherlands (NL)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
University of Bergen / Universitetet i Bergen
Norway (NO)
Haukeland University Hospital / Haukeland universitetssykehus
Norway (NO)
Universidade Federal do Rio Grande do Sul (UFRGS)
Brazil (BR)
Hospital de Clínicas de Porto Alegre (HCPA)
Brazil (BR)
Massachusetts General Hospital
United States (USA) (US)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Spain (ES)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
How to cite
APA:
Klein, M., Berger, S., Hoogman, M., Dammers, J., Makkinje, R., Heister, A.J.,... Franke, B. (2016). Meta-analysis of the DRD5 VNTR in persistent ADHD. European Neuropsychopharmacology, 26(9), 1527-1532. https://doi.org/10.1016/j.euroneuro.2016.06.012
MLA:
Klein, Marieke, et al. "Meta-analysis of the DRD5 VNTR in persistent ADHD." European Neuropsychopharmacology 26.9 (2016): 1527-1532.
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