Towards a blood-based diagnostic panel for bipolar disorder

Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM, Rothermundt M, van Beveren NJ, Crespo-Facorro B, Niebuhr DW, Cowan DN, Weber NS, Yolken RH, Penninx BW, Bahn S (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Brain Behavior and Immunity Elsevier

Book Volume: 52

Pages Range: 49-57

DOI: 10.1016/j.bbi.2015.10.001

Abstract

Background: Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic test for BD. Methods and findings: We performed a meta-analysis of eight case-control studies to define a diagnostic biomarker panel for BD. After validating the panel on established BD patients, we applied it to undiagnosed BD patients. We analysed 249 BD, 122 pre-diagnostic BD, 75 pre-diagnostic schizophrenia and 90 first onset major depression disorder (MDD) patients and 371 controls. The biomarker panel was identified using ten-fold cross-validation with lasso regression applied to the 87 analytes available across the meta-analysis studies.We identified 20 protein analytes with excellent predictive performance [area under the curve (AUC). ≥. 0.90]. Importantly, the panel had a good predictive performance (AUC 0.84) to differentiate 12 misdiagnosed BD patients from 90 first onset MDD patients, and a fair to good predictive performance (AUC 0.79) to differentiate between 110 pre-diagnostic BD patients and 184 controls. We also demonstrated the disease specificity of the panel. Conclusions: An early and accurate diagnosis has the potential to delay or even prevent the onset of BD. This study demonstrates the potential utility of a biomarker panel as a diagnostic test for BD.

Involved external institutions

University of Cambridge GB United Kingdom (GB) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE) Erasmus University Medical Center (MC) NL Netherlands (NL) Universidad de Cantabria (UC) ES Spain (ES) Walter Reed Army Institute of Research (WRAIR) US United States (USA) (US) Johns Hopkins Hospital US United States (USA) (US) Amsterdam University Medical Centers (Amsterdam UMC) / Amsterdam Universitair Medische Centra NL Netherlands (NL)

How to cite

APA:

Haenisch, F., Cooper, J.D., Reif, A., Kittel-Schneider, S., Steiner, J., Leweke, F.M.,... Bahn, S. (2016). Towards a blood-based diagnostic panel for bipolar disorder. Brain Behavior and Immunity, 52, 49-57. https://doi.org/10.1016/j.bbi.2015.10.001

MLA:

Haenisch, Frieder, et al. "Towards a blood-based diagnostic panel for bipolar disorder." Brain Behavior and Immunity 52 (2016): 49-57.

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