Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng ATA, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Del Zompo M, DePaulo JR, Detera-Wadleigh SD, Etain B, Falkai P, Frisén L, Frye MA, Fullerton J, Gard S, Garnham J, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn JP, Kassem L, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Kuo PH, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell PB, Mondimore F, Monteleone P, Nallet A, Neuner M, Novák T, O'Donovan C, Ösby U, Ozaki N, Perlis RH, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert OK, Schweizer B, Seemüller F, Grigoroiu-Serbanescu M, Severino G, Seymour LR, Slaney C, Smoller JW, Squassina A, Stamm T, Steele J, Stopkova P, Tighe SK, Tortorella A, Turecki G, Wray NR, Wright A, Zandi PP, Zilles D, Bauer M, Rietschel M, McMahon FJ, Schulze TG, Alda M (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Book Volume: 8

Article Number: e65636

Journal Issue: 6

DOI: 10.1371/journal.pone.0065636

Abstract

Objective:The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the "Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" scale currently used in the Consortium on Lithium Genetics (ConLiGen) study.Materials and Methods:Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling.Results:Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders).Conclusions:We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.

Authors with CRIS profile

Involved external institutions

Dalhousie University Canada (CA) Charité - Universitätsmedizin Berlin Germany (DE) National Institute of Mental Health Information Resource Center United States (USA) (US) Azienda Ospedaliera Universitaria di Cagliari Italy (IT) Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG) Switzerland (CH) Karolinska Institute Sweden (SE) Universidade Estadual de Campinas (UNICAMP) / University of Campinas Brazil (BR) University of Adelaide Australia (AU) Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal France (FR) Medizinische Universität Graz Austria (AT) Mayo Clinic United States (USA) (US) Academia Sinica / 中央研究院 Taiwan (TW) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Johns Hopkins Hospital United States (USA) (US) Institut Mondor de Recherche Biomédicale France (FR) Klinikum der Universität München (LMU Klinikum) Germany (DE) Neuroscience Research Australia NeuRA Australia (AU) Centre Hospitalier Charles Perrens (CHCP) France (FR) Mood Disorders Ottawa Canada (CA) Georg-August-Universität Göttingen Germany (DE) Poznan University of Medical Sciences / Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu Poland (PL) Centre Hospitalier Régional et Universitaire de Nancy (CHRU de Nancy / CHU de Nancy) France (FR) National Institute of Mental Health (NIMH) / Národní ústav duševního zdraví (NUDZ) Czech Republic (CZ) RIKEN Center for Brain Science (CBS) Japan (JP) Julius-Maximilians-Universität Würzburg Germany (DE) National Taiwan University (NTU) Taiwan (TW) Karolinska University Hospital / Karolinska Universitetssjukhuset Sweden (SE) Universidad de Antioquía (UDEA) Colombia (CO) Università degli Studi di Napoli Federico II Italy (IT) University of New South Wales (UNSW) Australia (AU) Fujita Health University Japan (JP) Massachusetts General Hospital United States (USA) (US) Technische Universität Dresden Germany (DE) Université de Montréal Canada (CA) "Prof. Dr. Alexandru Obregia" Clinical Hospital of Psychiatry / Spitalul Clinic de Psihiatrie Prof. Dr. Alexandru Obregia Romania (RO) Università degli Studi di Cagliari Italy (IT) Douglas Research Centre / Le Centre de Recherche Douglas Canada (CA) University of Queensland Australia (AU) Johns Hopkins University (JHU) United States (USA) (US) Universitätsklinikum Mannheim / University Medical Centre Mannheim (Universitätsmedizin Mannheim) Germany (DE)

How to cite

APA:

Manchia, M., Adli, M., Akula, N., Ardau, R., Aubry, J.M., Backlund, L.,... Alda, M. (2013). Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0065636

MLA:

Manchia, Mirko, et al. "Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report." PLoS ONE 8.6 (2013).

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