Utilizing Global Time-Delay Estimation for Axial and Lateral Displacement Computation in Magnetomotive Ultrasound

Huber C, Heim C, Rupitsch SJ, Ermert H, Ullmann I, Lyer S (2025)

Publication Type: Conference contribution

Publication year: 2025

Journal

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society

Publisher: Institute of Electrical and Electronics Engineers Inc.

Conference Proceedings Title: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Event location: Kopenhagen DK

ISBN: 9798331586188

DOI: 10.1109/EMBC58623.2025.11253545

Abstract

Magnetic nanoparticles (MNPs) are versatile tools in biomedical applications, serving as contrast agents in magnetic resonance imaging, mediators for localized tumor heating in magnetic hyperthermia, and carriers in magnetic drug targeting (MDT). Ultrasound-based techniques such as magnetomotive ultrasound (MMUS), photoacoustics, and magneto-thermo-acoustics have been established to visualize MNP distribution. Among these, MMUS has been widely demonstrated in various in vivo applications, utilizing the displacement of MNPs induced by an alternating magnetic field to map axial displacement fields. A current research area in MNP mapping is the quantification of MNP distribution, potentially achievable via inverse MMUS, where measured displacements are used to estimate particle concentrations in a voxel. However, inverse MMUS requires comprehensive knowledge of the three-dimensional displacement vector. Conventional MMUS methods primarily compute axial displacement. In this work, we present an approach employing global time-delay estimation to calculate both axial and lateral displacements within a two-dimensional ultrasound image.Clinical relevance - Ultrasound imaging and the corresponding quantification of magnetic nanoparticle distribution offer significant potential to enhance the application of magnetic nanoparticles in localized tumor therapy and sentinel lymph node detection. These advancements can improve patient outcomes during treatment and help prevent tumor metastasis.

Authors with CRIS profile

Christian Huber Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Helmut Ermert Professur für Nanomedizin Ingrid Ullmann Lehrstuhl für Hochfrequenztechnik (LHFT) Stefan Lyer Professur für KI-gesteuerte Nanomaterialien

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE)

How to cite

APA:

Huber, C., Heim, C., Rupitsch, S.J., Ermert, H., Ullmann, I., & Lyer, S. (2025). Utilizing Global Time-Delay Estimation for Axial and Lateral Displacement Computation in Magnetomotive Ultrasound. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Kopenhagen, DK: Institute of Electrical and Electronics Engineers Inc..

MLA:

Huber, Christian, et al. "Utilizing Global Time-Delay Estimation for Axial and Lateral Displacement Computation in Magnetomotive Ultrasound." Proceedings of the 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2025, Kopenhagen Institute of Electrical and Electronics Engineers Inc., 2025.

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