MINIATURIZED PIEZOELECTRIC MICRO PUMP-DRIVEN SYSTEM INTENDED FOR WEARABLE VACUUM-ASSISTED INTERSTITIAL FLUID SAMPLING VIA HOLLOW SILICON MICRONEEDLES

Zimmermann A, Martin N, Richter M, Fischer G (2026)

Publication Language: English

Publication Type: Conference contribution, Original article

Publication year: 2026

Book Volume: 6

Pages Range: 26-29

Conference Proceedings Title: Proceedings of the Microfluidic Handling Systems Conference 2026

Event location: Enschede NL

Open Access Link: https://www.utwente.nl/en/eemcs/mfhs2026/mfhs2026-proceedings.pdf

Abstract

Wearable interstitial fluid (ISF) sampling using hollow microneedles offers a minimally invasive approach for continuous biomarker monitoring. However, passive ISF extraction is limited by tissue resistance and typically requires external vacuum sources or needle removal. This work presents a miniaturized wearable system integrating hollow silicon microneedles with a piezoelectric micro diaphragm pump to provide continuous negative-pressure-assisted ISF extraction. Two prototype concepts were developed and experimentally validated. Peak negative gauge pressures of up to −38 kPa and flow rates of up to 8 mL/min were achieved under zero-backpressure laboratory conditions. In a separate pressure–flow characterization, flow rates of up to 11 mL/min were measured under controlled backpressure. The results demonstrate the feasibility of compact, integrated pressure generation for wearable ISF sampling and provide a basis for further miniaturization toward fully wearable biosensing platforms.

Authors with CRIS profile

Anne Zimmermann Professur für Technische Elektronik Georg Fischer Professur für Technische Elektronik

Involved external institutions

Fraunhofer-Einrichtung für Mikrosysteme und Festkörper-Technologien (EMFT) / Fraunhofer Research Institution for Microsystems and Solid State Technologies DE Germany (DE)

How to cite

APA:

Zimmermann, A., Martin, N., Richter, M., & Fischer, G. (2026). MINIATURIZED PIEZOELECTRIC MICRO PUMP-DRIVEN SYSTEM INTENDED FOR WEARABLE VACUUM-ASSISTED INTERSTITIAL FLUID SAMPLING VIA HOLLOW SILICON MICRONEEDLES. In Proceedings of the Microfluidic Handling Systems Conference 2026 (pp. 26-29). Enschede, NL.

MLA:

Zimmermann, Anne, et al. "MINIATURIZED PIEZOELECTRIC MICRO PUMP-DRIVEN SYSTEM INTENDED FOR WEARABLE VACUUM-ASSISTED INTERSTITIAL FLUID SAMPLING VIA HOLLOW SILICON MICRONEEDLES." Proceedings of the Microfluidic Handling Systems Conference 2026, Enschede 2026. 26-29.

BibTeX: Download