In vivo solid stress is associated with poor patient survival in glioma

Jaitner N, Shahryari M, Schattenfroh J, Meyer T, Aghamiry HS, Ludwig J, Jordan J, Janas A, Morr A, Huang B, Shams B, Picht T, Acker G, Schaeffter T, Guo J, Sack I (2026)

Publication Status: In review

Publication Type: Unpublished / Preprint

Future Publication Type: Journal article

Publication year: 2026

Original Authors: Noah Jaitner, Mehrgan Shahryari, Jakob Schattenfroh, Tom Meyer, Hossein S. Aghamiry, Jakob Ludwig, Jakob Jordan, Anastasia Janas, Anna Morr, Biru Huang, Boshra Shams, Thomas Picht, Gueliz Acker, Tobias Schaeffter, Jing Guo, Ingolf Sack

DOI: 10.48550/arXiv.2510.00009

Abstract

Solid stress is increasingly being recognized as a key driver of tumor progression and aggressiveness, yet it has not been directly measured in patients so far. Here, we combine multifrequency magnetic resonance elastography with 3D magnetic resonance imaging (MRI)-based diffeomorphic deformable image registration network analysis to noninvasively quantify glioma-induced solid stress. In both a mouse model and patients, we identified spatially heterogeneous deformation patterns extending well beyond tumor margins. While deformation magnitude was not found to correlate with tumor size or clinical outcome, excess solid stress - defined as the product of peritumoral volumetric strain and stiffness differential between unaffected brain and peritumoral tissue - was inversely associated with patient survival, highlighting its potential as a quantitative, imaging-derived biomarker. To our knowledge, this study provides the first direct quantification of mechanical stress in patients with glioma.

Authors with CRIS profile

Jing Guo Sonderforschungsbereich 1540/1 - Erforschung der Mechanik des Gehirns (EBM): Verständnis, Engineering und Nutzung mechanischer Eigenschaften und Signale in der Entwicklung, Physiologie und Pathologie des zentralen Nervensystems

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE) Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE)

How to cite

APA:

Jaitner, N., Shahryari, M., Schattenfroh, J., Meyer, T., Aghamiry, H.S., Ludwig, J.,... Sack, I. (2025). In vivo solid stress is associated with poor patient survival in glioma. (Unpublished, In review).

MLA:

Jaitner, Noah, et al. In vivo solid stress is associated with poor patient survival in glioma. Unpublished, In review. 2025.

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