P197: Investigating the Sequence Grammar of Age-Sensitive cis-Regulatory Elements in Neuronal Aging
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.07.2026
End date : 30.06.2027
Project details
Scientific Abstract
Why do some gene-control switches in neurons fail with age while others remain stable? Using genome-wide measurements of RNA, chromatin accessibility, and histone marks, we will map age-sensitive regulatory DNA in neurons and learn the sequence rules that predict vulnerability. Interpretable AI models will nominate key motifs and combinations, which we will test by targeted sequence edits and reporter assays in neuronal systems to pinpoint causal mechanisms and candidate intervention points.
